This study demonstrated that physical exercise pretreatment improves recognition memory and enhances structural synaptic plasticity in the hippocampus of Alzheimer’s disease (AD) rats, primarily through the activation of hippocampal TREM2. Blocking TREM2 diminished these neuroprotective effects, indicating that exercise mitigates synaptic injury and cognitive decline in AD via a TREM2-dependent mechanism.
This study provides evidence of distinct alterations in resting-state functional connectivity in individuals with amnestic mild cognitive impairment (aMCI) and late-life depression (LLD), underscoring region-specific vulnerabilities that may contribute to cognitive decline and depressive symptomatology in older adults.
The article describes the discovery and development of compound 8e, a selective and reversible butyrylcholinesterase (BuChE) inhibitor, as a potential therapeutic agent for treating Alzheimer's disease (AD). Compound 8e exhibited favorable blood-brain barrier permeability, good drug-likeness properties, and pronounced neuroprotective efficacy in various AD models, including zebrafish, scopolamine-induced mice, and APP/PS1 transgenic mice.
The article explores the strong link between metabolic syndrome and the development of Alzheimer's disease, with a focus on how dyslipidemia contributes to the underlying pathogenic mechanisms.
This study examined perceptions and awareness of brain health among Cuban youth through an online survey of 1,049 participants using the Global Brain Health Survey. Results showed that participants viewed the social environment as the most influential factor on brain health and were generally aware of conditions like Alzheimer’s and depression, but had limited understanding of the cognitive effects of chronic diseases such as hypertension and diabetes, underscoring the need for targeted public health education and awareness campaigns.
This study demonstrates that aerobic exercise, specifically swimming training, improves learning and memory in Alzheimer's disease model mice by enhancing glymphatic system function and promoting AQP4 polarization, which facilitates clearance of β-amyloid in the hippocampus. These findings suggest that exercise-induced upregulation of Lama1 and Dp71 supports glymphatic clearance mechanisms, thereby reducing Aβ deposition and cognitive impairment.
The article discusses the role of microglial activation in Alzheimer's disease (AD), highlighting its impact on neuroinflammation and cognitive dysfunction. It explores the molecular mechanisms underlying microglial activation, potential therapeutic targets, and updates on clinical trials for drugs aimed at mitigating neuroinflammation and cognitive decline in AD.
This article systematically summarizes the neuroprotective effects and mechanisms of ginsenosides Rg1, Rb1, and rare ginsenosides against Parkinson's disease (PD) and Alzheimer's disease (AD). The key findings indicate that ginsenosides exert their beneficial effects by modulating various signaling pathways related to inflammation, oxidative stress, apoptosis, and autophagy.
The article focuses on developing non-invasive blood-based biomarkers for early detection and risk assessment of Alzheimer's disease, highlighting the limitations of current diagnostic methods and the need for affordable, accessible, and robust alternatives. It also explores the connection between Alzheimer's and type 2 diabetes.
Elsevier,
Microbiota-Gut-Brain Axis and CNS Disorders: Recent Progress and Perspectives, 2025, pp 19-41
This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by discussing the understudied impacts of the gut microbiome and chronic inflammation that may contribute to neurodegeneration.
