AAV-aMTD-Parkin, a therapeutic gene delivery cargo, enhances motor and cognitive functions in Parkinson's and Alzheimer's diseases

Elsevier, Pharmacological Research, Volume 208, October 2024
Neurodegenerative disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD), have a global prevalence and profoundly impact both motor and cognitive functions.
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Psychological telephone triage system for outpatient memory clinics - a way for adaptation to new challenges of increasing dementia prevalence and new treatment options?

Elsevier,

International Journal of Clinical and Health Psychology, Volume 24, 1 October 2024
This study demonstrates that the Psychological Telephone Triage System (PTT) is an effective and cost-efficient method for early identification of patients with urgent cognitive impairment, particularly in the context of Alzheimer’s disease (AD), helping to reduce unnecessary on-site visits and healthcare burden. The findings suggest that implementing this interdisciplinary pre-screening and triage process can improve management of the rising demand for dementia assessments, especially with new therapeutic options and increasing prevalence of dementia globally.
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Health and wellbeing, Europe

Does Cognitive Stimulation Therapy show similar efficacy in individuals with mild-to-moderate dementia from varying etiologies? An examination comparing its effectiveness in Alzheimer's disease and vascular dementia

Elsevier,

International Journal of Clinical and Health Psychology, Volume 24, 1 October 2024
This study shows that the Cognitive Stimulation Therapy program can significantly improve general cognition, communication, and reduce depression in people living with dementia, regardless of the underlying pathology. However, the effects vary by dementia subtype, with some gains maintained long-term in vascular dementia (VaD) but not in Alzheimer, especially regarding narrative abilities and depressive symptoms, highlighting the importance of personalized approaches.
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Health and wellbeing; Health and population, Global

Fluid biomarkers in the context of amyloid-targeting disease-modifying treatments in Alzheimer's disease

Elsevier,

Med, Volume 5, 11 October 2024
In this review, Hu et al. summarize fluid biomarker findings across 12 anti-amyloid-β clinical trials. The emerging biomarker data provide evidence of impact of the new therapies on the underlying pathophysiological processes of the AD, supporting the presence of a disease-modifying effect.
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Health and wellbeing, Global

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Volume 1 (Seventh Edition): Chapter 7 - Pharmacogenomic approaches to the treatment of sporadic Alzheimer’s disease

Elsevier,

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Volume 1, Seventh Edition, 2025, pp 99-113
This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by discussing the role of genetic variants found to affect cholinergic and noncholinergic neurotransmission.
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Health and population; Health and wellbeing, Global

Novel Drug Delivery Systems in the management of CNS Disorders: Chapter 13 - Role of novel drug delivery systems in managing Alzheimer's disease

Elsevier,

Novel Drug Delivery Systems in the management of CNS Disorders, 2025, pp 199-214
This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by examining novel medications and drug delivery systems to advance the treatment of Alzheimer's Disease.
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Health and population; Health and wellbeing, Global

Integrating amyloid and tau imaging with proteomics and genomics in Alzheimer's disease

Elsevier,

Cell Reports Medicine, Volume 5, 17 September 2024
This review emphasizes that integrating amyloid and tau PET imaging with genomics and proteomics significantly advances our understanding of the biological mechanisms underlying Alzheimer’s disease, fostering greater awareness of dementia’s complexity and paving the way for improved diagnosis, prognosis, and personalized care.
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AAV-aMTD-Parkin, a therapeutic gene delivery cargo, enhances motor and cognitive functions in Parkinson's and Alzheimer’s diseases

Elsevier,

Pharmacological Research, Volume 208, October 2024, 107326

The article presents the development of a novel fusion delivery platform called AAV-aMTD-Parkin, which combines a hydrophobic cell-penetrating peptide sequence with the DNA sequences of AAV and Parkin. This innovative approach has demonstrated significant improvements in cell and tissue permeability, leading to the restoration of motor and cognitive function in animal models of Parkinson's disease (PD) and Alzheimer's disease (AD).

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Health and wellbeing; Health and population, Global

Resistance Exercise Reduces Sarcopenia by Repairing Leaky Gut in Patients With Alzheimer's Disease

Elsevier, Archives of Medical Research, Volume 55, July 2024
Purpose: Sarcopenia or age-associated muscle loss is common in patients with Alzheimer's disease (AD). We have previously demonstrated the contribution of a leaky gut to sarcopenia in AD.
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Health and wellbeing, Asia

Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: Chapter 16 - FDG-PET: Tryptamine-treated mouse model and Alzheimer's disease patients. Conceptual evolution of microbiota tryptamine role in human diseases

Elsevier,

Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: A Conceptual Evolution of the Role of Microbiota Tryptamine in Human Diseases, 2024, pp 253-267

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by highlighting the data demonstrating the role tryptamine plays in Alzheimer's Disease.

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Health and population; Health and wellbeing, Global

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