First-best climate policy is a uniform carbon tax which gradually rises over time. Civil servants have complicated climate policy to expand bureaucracies, politicians to create rents. Environmentalists have exaggerated climate change to gain influence, other activists have joined the climate bandwagon. Opponents to climate policy have attacked the weaknesses in climate research. The climate debate is convoluted and polarized as a result, and climate policy complex.
An international review of stormwater regulation and practices, especially for low-exposure, landscape irrigation schemes in urban environments, was undertaken with a view to identifying what could be used in Alberta, Canada. A general lack of clear guidance and regulation to manage stormwater quality and potential public health risks was identified, which could be hindering the uptake of stormwater schemes generally.
An effective response to climate change demands rapid replacement of fossil carbon energy sources. This must occur concurrently with an ongoing rise in total global energy consumption. While many modelled scenarios have been published claiming to show that a 100% renewable electricity system is achievable, there is no empirical or historical evidence that demonstrates that such systems are in fact feasible. Of the studies published to date, 24 have forecast regional, national or global energy requirements at sufficient detail to be considered potentially credible.
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disrupted sleep. The sleep deficits could be reversed and sleep could be enhanced when flies were administered the GABA-A agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP).
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relationship between sleep and amyloid β (Aβ) has been well established with disturbed sleep and increased wakefulness leading to increased Aβ production and decreased Aβ clearance; whereas Aβ deposition is associated with increased wakefulness and sleep disturbances. Aβ fluctuates with the sleep-wake cycle and is higher during wakefulness and lower during sleep.
This content aligns with Goal 3: Good Health as well as Goal 10: Reduced Inequalities by discussing insights into the regulation and induction of bnAbs based on the use of KI models.
The sustainability of water resources depends on the dynamic interactions among the environmental, technological, and social characteristics of the water system and local population. These interactions can cause supply-demand imbalances at diverse temporal scales, and the response of consumers to water use regulations impacts future water availability. This research develops a dynamic modeling approach to simulate supply-demand dynamics using an agent-based modeling framework that couple models of consumers and utility managers with water system models.
