Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

This study investigated the prevalence and impact of auditory agnosia for environmental sounds in individuals with Alzheimer’s disease (AD), finding that over half exhibited signs of this central auditory dysfunction along with a high rate of unrecognized peripheral hearing loss. Although these factors appeared independent and showed limited direct effect on measured quality of life, possibly due to sheltered living environments and lack of patient awareness, they jointly contribute to daily functional decline, highlighting the importance of early hearing assessment and intervention in AD management.
The article discusses the critical role of the mitochondrial contact site and cristae organizing system (MICOS) complex in the pathogenesis of Alzheimer's disease (AD). It highlights how MICOS abnormalities, including subunit dysfunction and interactions with disease-associated proteins, to hallmark AD pathologies such as amyloid-β accumulation, neurofibrillary tangle formation, and neuronal apoptosis. The article suggests that targeting MICOS subunits with pharmacological interventions may provide novel therapeutic insights for AD treatment.
Elsevier,

Journal of Prevention of Alzheimer's Disease, Volume 12, 1 June 2025

This article provides a narrative review of the relationships between modifiable lifestyle factors and plasma biomarkers of Alzheimer's disease (AD). The key findings are that better nutrition, more physical activity, and good sleep quality are associated with more favorable plasma AD biomarker profiles, potentially reflecting less cerebral AD pathology.
The article discusses the potential of glucagon-like peptide-1 (GLP-1) receptor agonists (GRA) as novel therapeutic agents for neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD). GRA have shown promising effects in modulating neuroinflammation, oxidative stress, mitochondrial and autophagic functions, and protein misfolding in preclinical studies. Clinical trials have demonstrated that GRA like exenatide, liraglutide, and lixisenatide can improve motor deficits in PD and cognitive function in AD patients.
The article discusses the need for and challenges of developing combination therapies for Alzheimer's disease, given the complex and multifactorial nature of the disease. As of 2024, there were 21 combination trials in the pipeline, primarily involving repurposed agents targeting processes like inflammation, senescence, and amyloid-tau interactions. Key challenges include distinguishing individual drug effects and managing the operational complexity of combination trials.f
This study indicates neurofibrillary tangles(NFT) level detection in patients with extracranial carotid atherosclerotic disease (ECAD) could enable earlier identification of those at high risk for developing Alzheimer's and other dementias, sometimes decades before symptoms. As blood-based assays to quantify NFT's are more clinically available, this could guide more targeted prevention and early treatment strategies for patients.
Focusing on the Vietnamese Mekong Delta (VMD), this study examines how drought and salinity intrusion from 2000 to 2020 influences rice cropping, aquaculture area, and rice yield across seven coastal provinces.

Head and neck cancer (HNC) is the sixth most prevalent cancer worldwide with a poor prognosis when diagnosed at advanced clinical stages. The main risk factors are tobacco consumption and alcohol abuse. The article discusses the use of liquid biopsies as a minimally invasive diagnostic tool for HPV-positive head and neck cancer, as it could improve access to early cancer detection and monitoring.

Elsevier,

The Journal of Climate Change and Health, 2025, 100459

The article discusses the integration of justice enablers, including recognitional, procedural, and distributive justice, into climate-health adaptation planning in South America.

International Day of Play 2026

The International Day of Play is observed each year on June 11. Proclaimed by the United Nations General Assembly in 2024, this day recognizes the essential role of play in human development. It aims to raise awareness, promote policy change, and support efforts to make play accessible for all—especially children—regardless of background or circumstance.

The Significance of Play

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