This study found that female 5XFAD mice exhibit early impairments in prefrontal-dependent cognitive functions and increased activity of prefrontal PV neurons, unlike their male counterparts. These findings suggest a potential mechanism for the higher risk of Alzheimer's disease in women, highlighting sex-specific early deregulation in the prefrontal cortex.
The study explores the use of a novel gene delivery system, AAV-aMTD-Parkin, to enhance motor and cognitive functions in animal models of Parkinson’s and Alzheimer’s diseases. This system improves the delivery efficiency of therapeutic proteins, potentially offering a new treatment approach for these neurodegenerative disorders.

It is Time to Prioritize Mental Health in the Workplace.

This perspective provides recommendations and strategies for the urban ecosystem rehabilitation of future cities, placing biodiversity and ecosystem services at the core of designing healthy and sustainable urban spaces.
Globalization, westernization, and urbanization over the last decades, leading to changes in dietary habits as well as food production, consequently, rising non-communicable diseases (NCDs) and environmental degradation. This study attempts to identify Thailand's dietary changes, considering health and sustainability aspects, and to determine correlations between these changes and NCD cases as well as environmental impacts (GHG emissions, land-, nitrogen-, phosphorus-use).
Addressing the environmental impacts of lithium mining requires a multifaceted approach, from innovative recycling technologies to reducing reliance on lithium, funding research into mining alternatives, and stringent regulations on lithium mining.
This article aligns with Goal 3: Good Health and Goal 10: Reduced Inequalities by highlighting the importance of postsecondary education (PSE) for adults with intellectual and developmental disabilities, which can enhance their educational and vocational opportunities, leading to improved health and well-being. By examining the benefits of PSE options and the supportive legislative frameworks, the article advocates for equitable access to education, helping to reduce disparities and promote inclusivity in higher education and beyond. Additionally, it emphasizes the positive impact of college experiences on personal development and community integration for individuals with disabilities.
What methods people use and/or have heard of others using for self-managed abortion (SMA) prior to coming to a health facility for abortion care. 4.2% respondends had attempted SMA, and 25% had heard of others attempting SMA. The most frequently attempted methods for self-management were taking herbs and/or vitamins (31% each) or hitting oneself/being hit (22.5%).

This content aligns with Goal 3: Good Health by highlighting the significant impact of sleep disorders on the physical, cognitive, and emotional well-being of children with autistic spectrum disorders (ASDs) and their families, emphasizing the importance of effective interventions such as parent-directed behavioral strategies and the careful use of melatonin. By advocating for a collaborative approach to treatment planning that involves parents and children, the content promotes a patient-centered model of care that can lead to better health outcomes. Additionally, it supports Goal 10: Reduced Inequalities by addressing the specific needs of children with ASDs and their families, ensuring that they have access to appropriate and evidence-based interventions that can improve their quality of life and reduce disparities in healthcare access and treatment effectiveness.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by examining novel medications and drug delivery systems to advance the treatment of Alzheimer's Disease.

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