Neurodegenerative diseases are a group of illnesses that cause gradual deterioration of the central and peripheral nervous systems, leading to loss of function and structure in neurons. There are various factors contributing to the development of neurological degeneration, and it is important to understand the interconnectedness of these factors and the underlying pathologies. They have a wide range of pathologies; some cause memory and cognitive problems, while others limit a person’s ability to move, communicate, breathe, etc. Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease, and amyotrophic lateral sclerosis are the most well-known neurodegenerative disorders to date. The chapter discusses the potential role of nutraceuticals in the prevention and treatment of neurodegenerative diseases, nutraceuticals, including soy, peanuts, and ginsenoside Rg1, have been found to have neuroprotective properties and can affect various signaling pathways involved in neuroprotection. Antioxidant vitamins, such as vitamin C and vitamin E, have been linked to a decreased risk of PD, according to epidemiological data. Bacosides have been tested in animal models and human volunteers for their therapeutic effects on neuroprotection and memory enhancement. Further dosage-dependent trials are needed to determine the precise dose and regimen for nutraceuticals like bacosides to be used effectively in AD prevention and treatment.
Elsevier, Nutraceutical Fruits and Foods for Neurodegenerative Disorders, 2024, pp 379-404
