Articles

This study examines the impact of tuition-free and compulsory lower secondary education policies in seven sub-Saharan African countries, using a differences-in-differences approach.

The article provides an overview of metal-organic framework (MOF)-based composite adsorbents for atmospheric water harvesting, discussing the hydrolytic stability of MOFs, recent advances in sorption-based water harvesting devices, and the challenges and prospects of MOF-based composite adsorbents. Key points include compositing MOFs with other functional materials to address limitations in water adsorption capacity and energy-intensive regeneration, and the factors affecting the hydrolytic stability of MOFs.

The article presents PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks to prioritize therapeutic targets for Alzheimer's disease (AD). PI4AD recovers clinically validated targets like APP and ESR1, confirming its prioritization efficacy. The framework identifies Ras signaling as a central therapeutic hub, complementing traditional amyloid/tau-focused approaches. Crosstalk analysis reveals critical nodal genes (e.g., HRAS and MAPK1) and drug repurposing opportunities, bridging genetic insights with pathway-level biology.

The article suggest that beta-amyloid protein (Aβ) has a significant indirect effect on neurogranin (Ng) through key synaptic mediators such as SYT1 and GAP43 during the preclinical stages of Alzheimer’s disease (AD). These findings highlight the crucial role of SYT1 and GAP43 in mediating beta-amyloid-induced synaptic dysfunction, offering potential early biomarkers and therapeutic targets for AD progression.