Elsevier,
Materials Today, Volume , 2025
The article provides an overview of metal-organic framework (MOF)-based composite adsorbents for atmospheric water harvesting, discussing the hydrolytic stability of MOFs, recent advances in sorption-based water harvesting devices, and the challenges and prospects of MOF-based composite adsorbents. Key points include compositing MOFs with other functional materials to address limitations in water adsorption capacity and energy-intensive regeneration, and the factors affecting the hydrolytic stability of MOFs.
Elsevier,
Acta Pharmaceutica Sinica B, Volume , 2025
The article presents PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks to prioritize therapeutic targets for Alzheimer's disease (AD). PI4AD recovers clinically validated targets like APP and ESR1, confirming its prioritization efficacy. The framework identifies Ras signaling as a central therapeutic hub, complementing traditional amyloid/tau-focused approaches. Crosstalk analysis reveals critical nodal genes (e.g., HRAS and MAPK1) and drug repurposing opportunities, bridging genetic insights with pathway-level biology.
Elsevier,
Geriatric Nursing, Volume 61, 1 January 2025
This review highlights how nurse practitioners can strengthen Alzheimer’s disease care by supporting earlier diagnosis and access to treatment, which is essential for maintaining quality of life. Expanding their role helps reduce barriers in the healthcare system, ensuring people with Alzheimer’s receive timely care that promotes better health and well-being.
Elsevier,
Acta Pharmaceutica Sinica B, Volume , 2025
The article discusses the potential of artificial intelligence (AI) in revolutionizing drug discovery for Alzheimer's disease (AD) and delirium. It explores how AI can facilitate target identification, small molecule and protein-based drug design, and optimization of pharmacokinetic properties to address the challenges in developing effective treatments for these two brain diseases.
Elsevier,
Neurologia Argentina, Volume , 2025
The article suggest that beta-amyloid protein (Aβ) has a significant indirect effect on neurogranin (Ng) through key synaptic mediators such as SYT1 and GAP43 during the preclinical stages of Alzheimer’s disease (AD). These findings highlight the crucial role of SYT1 and GAP43 in mediating beta-amyloid-induced synaptic dysfunction, offering potential early biomarkers and therapeutic targets for AD progression.
Elsevier,
International Journal of Educational Research Open, Volume 8, June 2025, 100437
This study evaluates Child Aid’s innovative teacher training program in rural Guatemalan indigenous schools, which combines workshops, instructional coaching, and provision of children’s literature to enhance reading comprehension and critical thinking.
Elsevier,
Journal of Water Process Engineering, Volume 69, January 2025
Emerging pollutants (EPs), such as pharmaceuticals and personal care products (particularly antibiotics) and microplastics, pose significant threats to global water quality and human health, leading to increased interest in the use of constructed wetlands (CWs) for their purification. This paper reviews the literature from 2014 to 2024 on CWs' effectiveness in removing various EPs.
