Elsevier,
Brain Research Bulletin, Volume 228, August 2025
This study investigated how repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training affects functional connectivity in both gray matter and white matter in patients with mild to moderate Alzheimer’s disease. Results showed that rTMS modulated activity in key brain regions, particularly within the limbic system, with changes in white matter connectivity correlating with cognitive improvements.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The study found that long-duration and high-intensity walking were associated with reduced amyloid-beta accumulation over 4 years, with the greatest benefits seen in those who started walking earlier in life. However, walking activity was not linked to changes in tau deposition, neurodegeneration, or white matter hyperintensities.
Elsevier,
Journal of Pharmacology and Experimental Therapeutics, Volume 392, August 2025
This review discusses the dual role of amyloid-beta (Aβ) in Alzheimer's disease (AD). While Aβ accumulation is a hallmark of AD pathology, soluble Aβ also plays a neuroprotective role in regulating synaptic plasticity and memory. The review explores the potential of anti-Aβ immunotherapy as a treatment strategy, highlighting the need to balance targeting toxic Aβ species while preserving the physiological functions of Aβ.`
Elsevier,
Pharmacological Research, Volume 218, August 2025
This article describes the discovery and characterization of FJMU1887, a novel brain-penetrant small-molecule inhibitor of Galectin-3 (Gal-3) identified through an AI-driven drug discovery platform. FJMU1887 demonstrated potent anti-inflammatory effects, reduced Aβ pathology, and improved cognitive function in Alzheimer's disease mouse models, highlighting its therapeutic potential for the treatment of Alzheimer's disease.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The article estimates the value-based price of a blood test for Alzheimer's disease pathology, finding it would be $290-$1150 in primary care and $450-$1950 in specialty care, projecting substantial cost savings.
Elsevier,
Current Developments in Nutrition, Volume 9, August 2025
The study demonstrates that adopting more climate-friendly diets, which typically involve reduced animal-based food consumption and lower absolute micronutrient intakes, does not substantially increase the risk of micronutrient deficiencies for most nutrients. These findings underscore the importance of assessing both dietary intake and actual nutrient status when evaluating the nutritional consequences of sustainable eating patterns, supporting the potential health and environmental benefits of shifting toward climate-friendly diets.
Elsevier,
iScience, Volume 28, 15 August 2025
This perspective highlights strategies for modeling salt tolerance mechanisms, including root system architecture adaptation, salt filtration, adaptation of plant hydraulics, ion compartmentalization, and stomatal responses, to improve model representation and prediction.
Elsevier,
Food Policy, Volume 135, August 2025
Low-income citizens show the highest support for food labeling and educational campaigns, viewing them as effective and less intrusive, while taxation and checkout prompts are least accepted due to perceived invasiveness. Policy support is strongly influenced by perceived effectiveness, intrusiveness, and individuals’ existing behaviors, suggesting tailored approaches are needed to improve acceptance and impact.
